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FABP4/5 inhibitor compound 2

Chemical Structure : FABP4/5 inhibitor compound 2

CAS No.: 1227413-92-4

FABP4/5 inhibitor compound 2

Catalog No.: PC-38572Not For Human Use, Lab Use Only.

FABP4/5 inhibitor compound 2 is a potent dual FABP4 and FABP5 inhibitor with Kd of 0.01 and 0.52 uM, respectively, reduces isoproterenol-stimulated lipolysis in mouse 3T3-L1 adipocytes with IC50 of 22 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FABP4/5 inhibitor compound 2 is a potent dual FABP4 and FABP5 inhibitor with Kd of 0.01 and 0.52 uM, respectively, reduces isoproterenol-stimulated lipolysis in mouse 3T3-L1 adipocytes with IC50 of 22 uM.
FABP4/5 inhibitor compound 2 inhibited basal or isoproterenol-stimulated lipolysis in 3T3-L1 and primary human adipocytes.
FABP4/5 inhibitor compound 2 inhibited basal and LPS-stimulated MCP-1 release from THP-1 cells and primary human macrophages.
FABP4/5 inhibitor compound 2 ameliorated dyslipidemia but not insulin resistance in DIO mice.

Physicochemical Properties

M.Wt 366.805
Formula C19H15ClN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((3-chloro-2-methylphenoxy)methyl)-2-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7(1H)-one

References

1. Hong Lan, et al. J Lipid Res. 2011 Apr;52(4):646-56.

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