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FAPI-46

Chemical Structure : FAPI-46

CAS No.: 2374782-04-2

FAPI-46 (Linofapib bentoxetan)

Catalog No.: PC-27470Not For Human Use, Lab Use Only.

FAPI-46 (Linofapib bentoxetan) is a quinoline-based fibroblast activation protein (FAP)-targeted tracer, FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation.

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1 mg $248 In stock
2 mg $398 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FAPI-46 (Linofapib bentoxetan) is a quinoline-based fibroblast activation protein (FAP)-targeted tracer, FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation.

Physicochemical Properties

M.Wt 885.97
Formula C41H57F2N11O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid, 10-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]methylamino]propyl]-1-piperazinyl]-2-oxoethyl]-

References

1. Loktev A, et, al. Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention. J Nucl Med. 2019 Oct;60(10):1421-1429.

2. Moon ES, et, al. EJNMMI Radiopharm Chem. 2020 Jul 29;5(1):19.

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