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Chemical Structure : FAPL-PI3Ki1
Catalog No.: PC-72075Not For Human Use, Lab Use Only.
FAPL-PI3Ki1 is a specific FAP-targeted PI3K inhibitor that selectively targets FAP-expressing human IPF lung fibroblasts and potently inhibits collagen synthesis.
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FAPL-PI3Ki1 is a specific FAP-targeted PI3K inhibitor that selectively targets FAP-expressing human IPF lung fibroblasts and potently inhibits collagen synthesis.
FAPL-PI3Ki1 significantly inhibited phosphorylation of Akt in IPF fibroblasts with IC50 of 200 nM, also inhibited phosphorylation of 4E-BP1.
FAPL-PI3Ki1 induced suppression of TGFb1-stimulated collagen production and phosphorylation of Akt in IPF fibroblasts requires participation of FAP.
FAPL-PI3Ki1 suppressed production of hydroxyproline (major building block of collagen), reduced collagen deposition, and increased mouse survival in a mouse model of IPF inhibited PI3K activation in fibrotic lungs.
| M.Wt | 1177.188 | |
| Formula | C52H48F4N10O12S3 | |
| Appearance | Solid | |
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1. Suraj U Hettiarachchi, et al. Sci Transl Med. 2020 Oct 28;12(567):eaay3724.
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