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Chemical Structure : FASN inhibitor C75
CAS No.: 218137-86-1
Catalog No.: PC-43005Not For Human Use, Lab Use Only.
FASN inhibitor C75 is a synthetic, slow-binding inhibitor of mammalian fatty acid synthesis (FASN, FAS), binds to and inhibits mammalian FAS and inhibits fatty acid synthesis in human cancer cells (SKBR3 cells ID50=5.0 ug/mL).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $298 | In stock | |
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| 100 mg | Get quote |
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FASN inhibitor C75 is a synthetic, slow-binding inhibitor of mammalian fatty acid synthesis (FASN, FAS), binds to and inhibits mammalian FAS and inhibits fatty acid synthesis in human cancer cells (SKBR3 cells ID50=5.0 ug/mL).
FASN inhibitor C75 causes changes in peripheral tissues, including inhibition of hepatic fatty acid synthesis, reduction of fatty liver, diminished adipose tissue mass, and high levels of malonyl-CoA.
FASN inhibitor C75 reduces food consumption and increases both fatty acid oxidation and energy expenditure in DIO mice.
FASN inhibitor C75 also sensitizes the efficacy of radiotherapy of prostate carcinoma.
| M.Wt | 254.3221 | |
| Formula | C14H22O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-Furancarboxylic acid, tetrahydro-4-methylene-2-octyl-5-oxo- |
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1. Kuhajda FP, et al. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3450-4.
2. Gao S, et al. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.
3. Thupari JN, et al. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.
4. Rae C, et al. Radiat Res. 2015 Nov;184(5):482-93.
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