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Chemical Structure : FCPR03
CAS No.: 1917347-65-9
Catalog No.: PC-62973Not For Human Use, Lab Use Only.
FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $148 | In stock | |
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 100 mg | Get quote |
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FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively.
FCPR03 displays >2,000-fold selectivity over other PDEs.
FCPR03 effectively increases the production of cAMP, promotes CREB phosphorylation, and inhibits NF-κB activation both in vitro and in vivo.
FCPR03 displays anti-neuroinflammation potential, promising antidepressant-like effects in vivo.
| M.Wt | 299.318 | |
| Formula | C15H19F2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(cyclopropylmethoxy)-4-(difluoromethoxy)-N-isopropylbenzamide |
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1. Zou ZQ, et al. J Pharmacol Exp Ther. 2017 Jul;362(1):67-77.
2. Zhou ZZ, et al. ACS Chem Neurosci. 2017 Jan 18;8(1):135-146.
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