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Chemical Structure : FG-0041
Catalog No.: PC-21729Not For Human Use, Lab Use Only.
FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.
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FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.
FG-0041 in low micromolar concentrations led to the dose-dependent accumulation of HIF1α in a variety of mammalian cells, accumulated transcriptionally active HIF.
FG-0041 also inhibits asparagine hydroxylation. FG-0041 was shown earlier to preserve left ventricular function in a rodent model of myocardial infarction.
| M.Wt | 240.22 | |
| Formula | C13H8N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mircea Ivan, et al. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64.
2. Nwogu J I, et al. Circulation. 2001;104:2216–2221.
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