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FGF-401

Chemical Structure : FGF-401

CAS No.: 1708971-55-4

FGF-401 (NVP-FGF401;Roblitinib;FGF401)

Catalog No.: PC-42406Not For Human Use, Lab Use Only.

FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FGF-401 (NVP-FGF401, Roblitinib, FGF401) is a first-in-class, potent, highly selective FGFR4 inhibitor with IC50 of 1.1 nM.
FGF-401 shows >1,000-fold selectivity against of panel of 65 kinases and in a kinome of 456 kinases.
FGF-401 potently inhibits phospho-FGFR4 in vivo, exhibits anti-tumor activity in s several xenograft animal models.

Physicochemical Properties

M.Wt 506.567
Formula C25H30N8O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 6 mg/mL (Need Ultrasonic)

Chemical Name/SMILES

1,8-Naphthyridine-1(2H)-carboxamide, N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-

References

1. Diana Graus Porta, et al. Abstract 2098: NVP-FGF401, a first-in-class highly selective and potent FGFR4 inhibitor for the treatment of HCC, AACR.

2. Patent WO2015059668A1, compound example 83.

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