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Chemical Structure : FIIN-2
CAS No.: 1633044-56-0
Catalog No.: PC-45474Not For Human Use, Lab Use Only.
FIIN-2 is a potent, irreversible inhibitor of FGFR with IC50 values of 3.1/ 4.3/27/45 nM for FGFR1/2/3/4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $256 | In stock | |
| 50 mg | $440 | In stock | |
| 100 mg | Get quote |
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FIIN-2 is a potent, irreversible inhibitor of FGFR with IC50 values of 3.1/ 4.3/27/45 nM for FGFR1/2/3/4.
FIIN-2 also inhibits FGFR2 mutants and EGFR, EGFR (L858R).
FIIN-2 avoids the steric clash with the gate-keeper mutation that causes the ponatinib resistance.
| M.Wt | 634.7274 | |
| Formula | C35H38N8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]- |
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1. Huang Z, et al. ACS Chem Biol. 2015 Jan 16;10(1):299-309.
2. Tan L, et al. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.
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