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Chemical Structure : FIIN-3
CAS No.: 1637735-84-2
Catalog No.: PC-45475Not For Human Use, Lab Use Only.
A selective, next-generation, covalent dual FGFR/EGFR inhibitor (IC50=1-60 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $176 | In stock | |
| 10 mg | $280 | In stock | |
| 50 mg | $960 | In stock | |
| 100 mg | $1480 | In stock |
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A selective, next-generation, covalent dual FGFR/EGFR inhibitor (IC50=1-60 nM); potently inhibits the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, also inhibits EGFR and EGFR (L858R); inhibits proliferation of the SKOV-3 cells with an EC50 of 499 nM.
| M.Wt | 691.6068 | |
| Formula | C34H36Cl2N8O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mg/mL |
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| Chemical Name/SMILES |
2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]- |
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1. Tan L, et al. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4869-77.
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