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FIM1033

Chemical Structure : FIM1033

CAS No.: 2018335-58-3

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FIM1033 (FIM-1033)

Catalog No.: PC-72410Not For Human Use, Lab Use Only.

FIM1033 (FIM-1033) is a potent small-molecule inhibitor of FimH with HAI EC90 of 8 nM, with antibiotica activities, significantly attenuated bacterial loads in pyelonephritis in treated mice.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FIM1033 (FIM-1033) is a potent small-molecule inhibitor of FimH with HAI EC90 of 8 nM, with antibiotica activities, significantly attenuated bacterial loads in pyelonephritis in treated mice.

    Physicochemical Properties

    M.Wt 429.469
    Formula C23H27NO7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    Chemical Name/SMILES

    7-(4-((1R)-hydroxy((3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-3-methylphenyl)-3,4-dihydroisoquinolin-1(2H)-one

    References

    1. Lisa K McLellan, et al. PLoS Pathog. 2021 Jan 29;17(1):e1009314.

    2. Laurel Mydock-McGrane, et al. J Med Chem. 2016 Oct 27;59(20):9390-9408.

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