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Chemical Structure : FIPI
CAS No.: 939055-18-2
Catalog No.: PC-43220Not For Human Use, Lab Use Only.
FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a potent, in vivo active phospholipase D (PLD) inhibitor with IC50 of 25 nM for both PLD1 and PLD2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a potent, in vivo active phospholipase D (PLD) inhibitor with IC50 of 25 nM for both PLD1 and PLD2.
FIPI inhibits both the hydrolytic and transphosphatidylation activities of PLD1 and PLD2, rapidly blocks in vivo phosphatidic acid (PA) production with subnanomolar potency (IC50=0.5 nM), does inhibit PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis。
FIPI attenuates mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells.
| M.Wt | 421.4674 | |
| Formula | C23H24FN5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 14.67 mg/mL |
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| Chemical Name/SMILES |
1H-Indole-2-carboxamide, N-[2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro- |
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1. Su W, et al. Mol Pharmacol. 2009 Mar;75(3):437-46.
2. Faugaret D, et al. Biochem Pharmacol. 2011 Jan 1;81(1):144-56.
3. Secor JD, et al. Int J Toxicol. 2011 Dec;30(6):619-38.
4. Olala LO, et al. Mol Cell Endocrinol. 2013 Feb 5;366(1):31-7.
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