FL118 | ADC payload, DDX5 inhibitor | Probechem Biochemicals

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Chemical Structure : FL118

CAS No.: 135415-73-5

FL118 (10,11-(Methylenedioxy)-20(S)-camptothecin)

Catalog No.: PC-26475Not For Human Use, Lab Use Only.

FL118 is a camptothecin derivative and payload for antibody-drug conjugates (ADCs) through topoisomerase I inhibition and proteasome-mediated degradation of anti-apoptotic proteins, also is a potent DDX5 (p68) degrader.

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10 mg	$98	In stock
25 mg	$158	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Physicochemical Properties

M.Wt	392.37
Formula	C21H16N2O6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-7-Ethyl-7-hydroxy-7H-[1,3]dioxolo[4,5-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-8,11(10H,13H)-dione

References

1. Mathi GR, et al. Bioorg Med Chem Lett. 2025 Apr 1;118:130085.

2. Ling X, et al. J Pharm Anal. 2024 Nov;14(11):101001.

3. Tago K, et al. J Biochem. 2026 Mar 26:mvag025.

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FL118 (10,11-(Methylenedioxy)-20(S)-camptothecin)

Biological Activity

Physicochemical Properties

References

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