Catalog No.: PC-23805Not For Human Use, Lab Use Only.
FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
FLIPinBγ does not act via modulating the protein level of c-FLIPL.
FLIPinBγ acts via enhancement of caspase-8 activity at the DISC.
c-FLIPL, the long isoform of c-FLIP, is a DED-containing protein and a key regulator of the extrinsic apoptosis pathway. DISC comprises DR, FADD, procaspase-8/10 and c-FLIPL/S/R proteins, DISC serves as a platform for procaspase-8 activation, which takes place upon its oligomerization in the death effector domain (DED)-filaments, initiating the apoptotic destruction of the cell.
