Chemical Structure : FLLL12
CAS No.:
917813-60-6
FLLL12
Catalog No.: PC-28218Not For Human Use, Lab Use Only.
FLLL12 is a curcumin analogue and STAT3 inhibitor, effectively inhibits STAT3, AKT, and HER2/neu pathways, inhibits STAT3 DNA binding and STAT3 transcriptional activity
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FLLL12 is a curcumin analogue and STAT3 inhibitor, effectively inhibits STAT3, AKT, and HER2/neu pathways, inhibits STAT3 DNA binding and STAT3 transcriptional activity
FLLL12 inhibits cell viability in eight different breast and prostate cancer cell lines with IC50 of 0.3-3.8 uM.
FLLL12 inhibits AKT phosphorylation and downregulate the expression of HER2/neu.
FLLL12 inhibits phosphorylation of signal transducer and activator of transcription 3 (STAT3).
FLLL12 inhibits cancer cell growth and migration.
FLLL12 effectively inhibit STAT3, AKT, and HER2/neu pathways.
Physicochemical Properties
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M.Wt
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386.40
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Formula
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C21H22O7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(1E,4E)-1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one
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References
1. Cen L, et al. BMC Cancer. 2009 Mar 30;9:99.
2. Friedman L, et al. Anticancer Drugs. 2009 Jul;20(6):444-9.
3. Lin L, et al. Cancer Sci. 2009 Sep;100(9):1719-27.
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