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Chemical Structure : FLT3 inhibitor 17
Catalog No.: PC-21367Not For Human Use, Lab Use Only.
FLT3 inhibitor 17 is a potent, highly selective FLT3 inhibitor with IC50 of 1.2 nM and 1.4 nM for FLT3 WT and FLT3-D835Y, shows low activity against VEGFR, FGFR, PDGFR, c-KIT, and RET.
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FLT3 inhibitor 17 is a potent, highly selective FLT3 inhibitor with IC50 of 1.2 nM and 1.4 nM for FLT3 WT and FLT3-D835Y, shows low activity against VEGFR, FGFR, PDGFR, c-KIT, and RET.
FLT3 inhibitor 17 inhibits FLT3 WT, FLT3-ITD and FLT3 D835Y with IC50 of ~1 nM, weakly inhibits c-KIT and RET with IC50 of 837 nM and 18000 nM.
FLT3 inhibitor 17 shows very limited activity against cardiovascular kinases FGFR1/2 and PDGFRα/β, with IC50 values >2690 nM, also displays minimal inhibition of over 180 other kinases.
FLT3 inhibitor 17 exhibits antiproliferative effects on Molm14cell lines containing mutated FLT3:Molm-14 (FLT3-ITD), Molm-14 (FLT3-ITD/D835Y) and Molm-14 (FLT3-ITD/F691L) with GI50 values of 2-23 nM, reduces the levels of phosphorylated FLT3 in Molm-14 cells.
| M.Wt | 374.45 | |
| Formula | C21H22N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sintim HO, et al. ChemMedChem. 2023 Nov 16:e202300442.
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