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Chemical Structure : FMK
CAS No.: 821794-92-7
Catalog No.: PC-45920Not For Human Use, Lab Use Only.
An irreversible inhibitor of the CTD of RSK1 and RSK2 with IC50 of 15 nM for wt RSK2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $144 | In stock | |
| 10 mg | $256 | In stock | |
| 25 mg | $512 | In stock | |
| 100 mg | Get quote |
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An irreversible inhibitor of the CTD of RSK1 and RSK2 with IC50 of 15 nM for wt RSK2; shows 600- and 200-fold selectivity over the C436V and T493M mutants, respectively; inhibits EGF-induced Ser386 phosphorylation of endogenous RSK2 in COS-7 cells (IC50=200 nM); also potently inhibits a Fyn mutant in which Val285 was replaced with Cys(IC50=100 nM), weakly inhibits WT Fyn with IC50 of 4 uM.
| M.Wt | 342.3675 | |
| Formula | C18H19FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Ethanone, 1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoro- |
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1. Cohen MS, et al. Science. 2005 May 27;308(5726):1318-21.
2. Cohen MS, et al. Nat Chem Biol. 2007 Mar;3(3):156-60. Epub 2007 Jan 28.
3. Kang S, et al. Cancer Cell. 2007 Sep;12(3):201-14.
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