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FOY-251

Chemical Structure : FOY-251

CAS No.: 71079-09-9

FOY-251 (FOY251)

Catalog No.: PC-49155Not For Human Use, Lab Use Only.

FOY-251 is a camostat metabolite and inhibitor of TMPRSS2 protease activity with IC50 of 33.3 nM, completely suppresses TMPRSS2 activity at 1 uM, inhibit SARS-2-S-driven cell entry with comparable efficiency (EC50=178 nM) with camostat mesylate.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

FOY-251 is a camostat metabolite and inhibitor of TMPRSS2 protease activity with IC50 of 33.3 nM, completely suppresses TMPRSS2 activity at 1 uM, inhibit SARS-2-S-driven cell entry with comparable efficiency (EC50=178 nM) with camostat mesylate.

Physicochemical Properties

M.Wt 409.413
Formula C17H19N3O7S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-((4-guanidinobenzoyl)oxy)phenyl)acetic acid compound with methanesulfonic acid (1:1)

References

1. Shrimp JH, et al. bioRxiv. 2020 Aug 6:2020.06.23.167544.

2. Hoffmann M, et al. EBioMedicine. 2021 Mar;65:103255.

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