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Chemical Structure : FPND
Catalog No.: PC-61252Not For Human Use, Lab Use Only.
FPND (FPMINT) is a novel specific ROCK1 kinase inhibitor with IC50 of 11.2 uM, without inhibitory activity against ROCK2.
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FPND (FPMINT) is a novel specific ROCK1 kinase inhibitor with IC50 of 11.2 uM, without inhibitory activity against ROCK2.
FPND (FPMINT) prevents atorvastatin-induced cerebral hemorrhage in zebrafish embryos (IC50=17.49 uM), by enhancing endothelial cell-cell junctions through inhibiting the ROCK-mediated VE-cadherin signaling pathway.
FPMINT is a potent equilibrative nucleoside transporters (ENTs) inhibitor, more selective to ENT2 than to ENT1.
| M.Wt | 429.503 | |
| Formula | C24H24FN7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Li S, et al. Cell Death Discov. 2017 Aug 21;3:17051.
2. Renkai Li, et al. Front Pharmacol. 2022 Feb 21;13:837555.
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