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Chemical Structure : FPR agonist Compound 43
Catalog No.: PC-72086Not For Human Use, Lab Use Only.
FPR agonist Compound 43 is a potent agonist of human formyl-peptide-like 1 receptor (hFPRL1) with EC50 of 44 nM (hFPRL1-mediated Ca2+ mobilization).
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FPR agonist Compound 43 is a potent agonist of human formyl-peptide-like 1 receptor (hFPRL1, FPR2) with EC50 of 44 nM (hFPRL1-mediated Ca2+ mobilization).
FPR agonist Compound 43 inhibited neutrophil (PMN) migration with IC50 of 1 uM.
FPR agonist Compound 43 showed a dose-dependent inhibition of ear swelling in mice following oral administration.
| M.Wt | 384.864 | |
| Formula | C20H21ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheng Xue Qin, et al. Nat Commun. 2017 Feb 7;8:14232.
2. Agostino Cilibrizzi, et al. J Med Chem. 2009 Aug 27;52(16):5044-57.
3. Crocetti L, et al. Molecules. 2021 Oct 30;26(21):6583.
4. Roland W Bürli, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8.
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