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Chemical Structure : FQI2-34
Catalog No.: PC-22044Not For Human Use, Lab Use Only.
FQI2-34 is a small molecule inhibitor of late SV40 factor (LSF, encoded by TFCP2) and β-catenin interaction, suppresses Wnt activity in CRC cells.
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FQI2-34 is a small molecule inhibitor of late SV40 factor (LSF, encoded by TFCP2) and β-catenin interaction, specifically inhibits LSF DNA-binding, partner protein-binding, and transactivation activities, suppresses Wnt activity in CRC cells.
FQI2-34 at 1 μmol/L concentrations consistently reduced LSF–β-catenin interaction in different CRC cell lines.
FQI2-34 reduced colocalization of late SV40 factor (LSF) and β-catenin in colorectal cancer cell lines.
FQI2-34 (1-20 uM) inhibited Wnt activity in CRC cell lines irrespective of their Wnt status.
FQI2-34 suppressed β-catenin in both digitonin and nondigitonin fractions, decreased levels of cytosolic β-catenin in CRC cell lines.
FQI2-34 (5 mg/kg daily for 5 consecutive days each week). suppressed growth and Wnt targets in allogeneic colorectal cancer xenograft.
| M.Wt | 352.39 | |
| Formula | C20H20N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lotfollahzadeh S, et al. Am J Pathol. 2022 Aug;192(8):1167-1185.
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