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Chemical Structure : FR 180204
CAS No.: 865362-74-9
Catalog No.: PC-42937Not For Human Use, Lab Use Only.
FR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $85 | In stock | |
| 10 mg | $125 | In stock | |
| 25 mg | $195 | In stock | |
| 100 mg | Get quote |
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FR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively.
FR 180204 inhibits TGFβ-induced luciferase-expression in mink lung epithelial Mv1Lu cells.
FR 180204 decreases plasma anti-CII antibody levels and attenuates delayed-type hypersensitivity in CII-immunized DBA/1 mice, also inhibits in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice.
FR 180204 enhances apoptotic and anti-proliferative effects of Akt inhibitor API-1 in human DLD-1 and LoVo colorectal cancer cells.
| M.Wt | 327.3427 | |
| Formula | C18H13N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 50 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)- |
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1. Ohori M, et al. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63.
2. Ohori M, et al. Naunyn Schmiedebergs Arch Pharmacol.
3. Chen-Roetling J, et al. Neuropharmacology. 2009 Apr;56(5):922-8.
4. Saglam AS, et al. Oncol Lett. 2016 Oct;12(4):2463-2474.
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