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Chemical Structure : FT113
Catalog No.: PC-72348Not For Human Use, Lab Use Only.
FT113 (FT-113) is a potent inhibitor of fatty acid synthase (FASN) with IC50 of 213 nM (hFASN).
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FT113 (FT-113) is a potent inhibitor of fatty acid synthase (FASN) with IC50 of 213 nM (hFASN).
FT113 showed anti-proliferative activity against prostate (PC3 cell line), breast (BT-474 cell line), and leukemia (MV-411 cell line, IC50=26 nM) cancer cells.
FT113 exhibited tumor growth inhibition of 32% and 50% by treatment with 25 and 50 mg/kg, respectively, increased malonyl-CoA levels in vivo.
| M.Wt | 409.417 | |
| Formula | C22H20FN3O4 | |
| Appearance | Solid | |
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1. Matthew W Martin, et al. Bioorg Med Chem Lett. 2019 Apr 15;29(8):1001-1006.
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