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Chemical Structure : FTI-277
CAS No.: 170006-73-2
Catalog No.: PC-44766Not For Human Use, Lab Use Only.
FTI-277 is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $68 | In stock | |
| 5 mg | $108 | In stock | |
| 10 mg | $178 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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FTI-277 is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
FTI-277 highly selective for FTase over GGTase I (IC50 = 50 nM).
FTI-277 extremely potent (IC50=100 nM) at inhibiting H-Ras in whole cells.
FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm.
| M.Wt | 447.614 | |
| Formula | C22H29N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester |
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1. Lerner EC, et al. J Biol Chem. 1995 Nov 10;270(45):26802-6.
2. Bernhard EJ, et al. Cancer Res. 1996 Apr 15;56(8):1727-30.
3. Bolick SC, et al. Leukemia. 2003 Feb;17(2):451-7.
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