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Chemical Structure : FTO-04
CAS No.: 2585198-87-2
Catalog No.: PC-72226Not For Human Use, Lab Use Only.
FTO-04 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 3.39 uM, 13-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=39.4 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $458 | In stock | |
| 100 mg | Get quote |
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FTO-04 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 3.39 uM, 13-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=39.4 uM).
FTO-04 prevented neurosphere formation in patient-derived glioblastoma stem cells (GSCs) without inhibiting the growth of healthy neural stem cell-derived neurospheres.
FTO-04 increased m6A and m6Am levels in GSCs consistent with FTO inhibition.
| M.Wt | 258.299 | |
| Formula | C12H10N4OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (2.59 mg/mL) |
|
| Chemical Name/SMILES |
6-(2-methoxypyrimidin-5-yl)benzo[d]thiazol-2-amine |
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1. Sarah Huff, et al. ACS Chem Biol. 2021 Feb 19;16(2):324-333.
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