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Chemical Structure : FTO-43
Catalog No.: PC-49236Not For Human Use, Lab Use Only.
FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).
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FTO-43 (FTO-43 N) is a potent, selective inhibitor of the m6A demethylase fat mass- and obesity-associated protein (FTO) with IC50 of 1.0 uM, no significant acitivity against the homologous m6A RNA demethylase ALKBH5 (IC50>40 uM).
FTO-43 N shows potent antiproliferative effects in glioblastoma, acute myeloid leukemia, and gastric cancer models (SNU-16 cells, IC50=17.7 uM).
FTO-43 N increases m6A and m6Am levels in gastric cancer cells consistent with FTO knockdown, downregulates Wnt/PI3K-Akt signaling in AGS gastric cancer cells.
| M.Wt | 346.855 | |
| Formula | C19H23ClN2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sarah Huff, et al. J Med Chem. 2022 Aug 8. doi: 10.1021/acs.jmedchem.1c02075.
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