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Chemical Structure : FX1
CAS No.: 1426138-42-2
Catalog No.: PC-60927Not For Human Use, Lab Use Only.
FX1 (BCL6 inhibitor FX1) is a potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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FX1 (BCL6 inhibitor FX1) is a potent, specific BCL6 BTB domain inhibitor with Kd of 7 uM, binds with a greater affinity than the natural BCL6 ligand SMRT (Kd=30 uM).
FX1 exhibits 10-fold greater inhibitory activity against the BCL6 BTB domain in reporter assays with IC50 of 35 uM, displays good selectivity against a panel of 50 different kinases.
FX1 disrupts formation of the BCL6 repression complex, reactivates BCL6 target genes, suppresses ABC-DLBCL cells in vitro and in vivo, as well as primary human ABC-DLBCL specimens ex vivo.
| M.Wt | 368.806 | |
| Formula | C14H9ClN2O4S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mg/mL in DMSO |
|
| Chemical Name/SMILES |
(Z)-3-(5-(5-chloro-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)propanoic acid |
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1. Cardenas MG, et al. J Clin Invest. 2016 Sep 1;126(9):3351-62.
2. Deb D, et al. Cancer Res. 2017 Jun 1;77(11):3070-3081.
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