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Chemical Structure : Fabimycin
Catalog No.: PC-49315Not For Human Use, Lab Use Only.
Fabimycin is a potent, specific inhibitor of the enoyl-acyl carrier protein reductase enzyme FabI, exhibits impressive activity against >200 clinical isolates of Escherichia coli, Klebsiella pneumoniae (MIC, 1 ug/mL), and Acinetobacter baumannii, and does not kill commensal bacteria.
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Fabimycin is a potent, specific inhibitor of the enoyl-acyl carrier protein reductase enzyme FabI, exhibits impressive activity against >200 clinical isolates of Escherichia coli, Klebsiella pneumoniae (MIC, 1 ug/mL), and Acinetobacter baumannii, and does not kill commensal bacteria.
Fabimycin potently inhibits A. baumannii and E. coli FabI with IC50 of <10 nM in enzyme assays.
Fabimycin inhibited 90% of a panel of 100 K. pneumoniae clinical isolates at 4 μg/mL, relative to 32 μg/mL for levofloxacin.
Fabimycin demonstrates in vivo efficacy in murine urinary tract infection (UTI).
| M.Wt | 440.928 | |
| Formula | C23H25ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Erica N Parker, et al. ACS Cent Sci. 2022 Aug 24;8(8):1145-1158.
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