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Fadrozole hydrochloride

Chemical Structure : Fadrozole hydrochloride

CAS No.: 102676-31-3

Fadrozole hydrochloride (CGS 16949A;FAD286;FAD 286)

Catalog No.: PC-60699Not For Human Use, Lab Use Only.

A potent and selective, orally bioavailable aromatase inhibitor with IC50 of 1.7 nM, 180 times more potent than aminoglutethimide.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent and selective, orally bioavailable aromatase inhibitor with IC50 of 1.7 nM, 180 times more potent than aminoglutethimide; lowers ovarian estrogen synthesis by gonadotropin-primed, androstenedione treated mice, suppresses hormone-dependent and -independent tumors in vivo.

Breast Cancer

Approved

Physicochemical Properties

M.Wt 259.737
Formula C14H14ClN3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile hydrochloride

References

1. Steele RE, et al. Steroids. 1987 Jul-Sep;50(1-3):147-61.

2. Schieweck K, et al. Cancer Res. 1988 Feb 15;48(4):834-8.

3. Juniewicz PE, et al. J Urol. 1988 Apr;139(4):827-31.

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