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Fam20C inhibitor 3r

Chemical Structure : Fam20C inhibitor 3r

CAS No.: 2615358-19-3

Fam20C inhibitor 3r

Catalog No.: PC-49525Not For Human Use, Lab Use Only.

Fam20C inhibitor 3r is a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Fam20C inhibitor 3r is a novel small-molecule inhibitor of Fam20C that induces apoptosis and inhibits migration in triple negative breast cancer.
Fam20C inhibitor 3r has strong anti-proliferative activity in MDA-MB-231 cells, with an IC50 = 5.986 μM.
Fam20C inhibitor 3r induces apoptosis and exerts obvious anti-migration activity in MDA-MB-231 cells.
Fam20C inhibitor 3r has good therapeutic potential in TNBC xenograft model without apparent toxicity.

Physicochemical Properties

M.Wt 537.59
Formula C26H27N5O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-methoxy-N-(4-((4-((3,4,5-trimethoxyphenyl)amino)pyrimidin-2-yl)amino)phenyl)benzenesulfonamide

References

1. Rongyan Zhao, et al. Eur J Med Chem. 2021 Jan 15;210:113088.

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