Fenobam

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Chemical Structure : Fenobam

CAS No.: 57653-26-6

Catalog No.: PC-26043Not For Human Use, Lab Use Only.

Fenobam is a potent, selective, BBB-penetrant and orally active mGluR5 antagonist with IC50 of 84 nM.

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10 mg	$88	In stock
25 mg	$148	In stock
50 mg	$248	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Fenobam is a potent, selective, BBB-penetrant and orally active mGluR5 antagonist with IC50 of 84 nM.
Fenobam has Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively.
Fenobam shows anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells.

Physicochemical Properties

M.Wt	266.69
Formula	C11H11ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea

References

1. Pecknold JC, et al. J Clin Psychopharmacol. 1982 Apr;2(2):129-33.

2. Porter RH, et al. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.

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Fenobam

Biological Activity

Physicochemical Properties

References

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