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Chemical Structure : Fezolinetant
CAS No.: 1629229-37-3
Catalog No.: PC-70195Not For Human Use, Lab Use Only.
Fezolinetant (ESN-364) is a potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Fezolinetant (ESN-364) is a potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6.
Fezolinetant (ESN-364) exhibits high activity in LH inhibition, shows >2.5-log selectivity against NK1R and NK2R subtypes, proves >300-fold selective against related HPG axis receptors (KOR, GnRH, GnIH-R, GPR54).
| M.Wt | 358.3954 | |
| Formula | C16H15FN6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[(8R)-5,6-Dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)methanone |
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1. Hoveyda HR, et al. ACS Med Chem Lett. 2015 May 19;6(7):736-40.
2. Fraser GL, et al. Endocrinology. 2015 Nov;156(11):4214-25.
3. Fraser GL, et al. J Clin Endocrinol Metab. 2016 Feb;101(2):417-26.
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