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Chemical Structure : Firuglipel
Catalog No.: PC-60042Not For Human Use, Lab Use Only.
Firuglipel (DS-8500, DS8500a) is a novel potent, selective, orally available GPR119 agonist with EC50 of 51.5 nM in human GPR119-expressing CHO-K1 cells, displays no significant effect on 66 receptors, channels, or transporters.
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Firuglipel (DS-8500, DS8500a) is a novel potent, selective, orally available GPR119 agonist with EC50 of 51.5 nM in human GPR119-expressing CHO-K1 cells, displays no significant effect on 66 receptors, channels, or transporters; enhances glucose-stimulated insulin secretion in Sprague-Dawley rats and promotes GLP-1 secretion in Zucker fatty rats, preserved β cell function and prevented increases in glycohemoglobin concentrations in rodent models of type 2 diabetes.
Diabetes
Phase 2 Clinical
| M.Wt | 467.497 | |
| Formula | C25H26FN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patent WO2012050151.
2. Inagaki N, et al. BMJ Open Diabetes Res Care. 2017 Sep 29;5(1):e000424.
3. Terauchi Y, et al. J Diabetes Investig. 2018 Apr 1. doi: 10.1111/jdi.12846.
4. Makino C, et al. Xenobiotica. 2018 Aug 20:1-33. doi: 10.1080/00498254.2018.1514545.
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