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Chemical Structure : Flavokawain B
Catalog No.: PC-35324Not For Human Use, Lab Use Only.
Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression.
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Flavokawain B is a natural chalcone that can induce apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50=3-50 uM), via up-regulation of death-receptor 5 and Bim expression; induces apoptosis in human myeloid leukemic cells by modifying NF-κB, possesses potential anti-inflammation and anti-cancer activities; also exhibits significant inhibition of the neurogenic nociceptive induced by intraplantar injections of glutamate and capsaicin in mice.
| M.Wt | 284.311 | |
| Formula | C17H16O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tang Y, et al. Int J Cancer. 2010 Oct 15;127(8):1758-68.
2. Lee JJ, et al. Anticancer Res. 2018 May;38(5):2771-2778.
3. Mohamad AS, et al. Eur J Pharmacol. 2010 Nov 25;647(1-3):103-9.
4. Abu N, et al. Nat Prod Commun. 2015 Jul;10(7):1199-202.
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