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Chemical Structure : Flavopiridol
CAS No.: 146426-40-6
Catalog No.: PC-42049Not For Human Use, Lab Use Only.
A potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $56 | In stock | |
| 50 mg | $248 | In stock |
Bulk size, bulk discount!
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A potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively; inhibits cell cycle progression in either G1 or G2 in human breast carcinoma cells, induces programmed cell death, promote differentiation, inhibits angiogenic processes and modulates transcriptional events.
Blood Cancer
Phase 2 Clinical
| M.Wt | 401.8402 | |
| Formula | C21H20ClNO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]- |
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1. De Azevedo WF Jr, et al. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2735-40.
2. Carlson BA, et al. Cancer Res. 1996 Jul 1;56(13):2973-8.
3. Senderowicz AM, et al. Invest New Drugs. 1999;17(3):313-20.
4. Kim KS, et al. J Med Chem. 2000 Nov 2;43(22):4126-34.
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