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Chemical Structure : Foldlin
Catalog No.: PC-20637Not For Human Use, Lab Use Only.
Foldlin is a small-molecule tool compound that reduces the protein levels of misfolded/aggregated mutant p53, without effect on contact mutants or wild-type p53, Foldlin is small-molecule HSF-1 activator.
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Foldlin is a small-molecule tool compound that reduces the protein levels of misfolded/aggregated mutant p53, without effect on contact mutants or wild-type p53, Foldlin is small-molecule HSF-1 activator.
Foldlin prevents the formation of stress-induced p53 nuclear inclusion bodies.
Foldlin is able to induce a broad-spectrum heat shock response in the Saos2 osteosarcoma cell line, increases the mRNA and protein expression of HSP70.
Foldlin induces HSF-1-dependent chaperone expression and restore protein folding in multiple conformational disease models.
Foldlin also reduces protein levels of aggregating SOD1 variants.
| M.Wt | 332.36 | |
| Formula | C20H16N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Evelyne Naus, et al. Cells. 2023 Mar 21;12(6):960.
2. Calamini B, et al. Nat. Chem. Biol. 2011;8:185–196.
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