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Chemical Structure : Foliglurax
Catalog No.: PC-60512Not For Human Use, Lab Use Only.
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM.
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A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM; shows more than 15-, 110- and 50-times higher selectivity for mGluR4 than for mGluR6, -7, and -8, respectively, no effect on NMDA, AMPA, kainate, group I or group II mGluRs, COMT, MAO-A or MAO-B (IC50>10 uM); demonstrates significant antiparkinsonian activity in rodent models of PD motor symptoms.
Parkinson Disease
Phase 2 Clinical
| M.Wt | 421.515 | |
| Formula | C23H23N3O3S | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Charvin D, et al. J Med Chem. 2017 Oct 26;60(20):8515-8537.
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