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Chemical Structure : Fosgonimeton
Catalog No.: PC-38394Not For Human Use, Lab Use Only.
Fosgonimeton (ATH-1017, ATH-1001 prodrug) is a highly specific, small-molecule positive modulator of the HGF/MET neurotrophic system, is a prodrug that rapidly converts into the active metabolite ATH-1001 in plasma.
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Fosgonimeton (ATH-1017, ATH-1001 prodrug) is a highly specific, small-molecule positive modulator of the HGF/MET neurotrophic system, is a prodrug that rapidly converts into the active metabolite ATH-1001 in plasma.
ATH-1001 crosses the blood-brain barrier and enhances the interaction of HGF with its receptor tyrosine kinase MET, inducing downstream signaling through PI3k/Akt and MAPK pathways and augmenting NMDA receptor-mediated long-term potentiation through PKC.
Fosgonimeton (ATH-1017) demonstrates potential with Alzheimer's disease (AD) and dementia, potentially improving dementia symptoms and altering disease progression by reversing synaptic disconnection and neuronal loss.
| M.Wt | 584.651 | |
| Formula | C27H45N4O8P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Xue Hua, et al. J Alzheimers Dis. 2022;86(3):1399-1413.
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