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Chemical Structure : Fostamatinib
CAS No.: 901119-35-5
Catalog No.: PC-43349Not For Human Use, Lab Use Only.
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | $528 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM。
Fostamatinib (R788) dose-dependently inhibits anti-IgE-mediated CHMC degranulation with an EC50 of 56 nM, inhibits all phosphorylation events downstream of Syk signaling。
Fostamatinib (R788) specifically inhibits FcγR signaling in human mast cells, macrophages, and neutrophils. R788 can inhibit local inflammatory injury mediated by immune complexes。
Fostamatinib (R788) reduces immune complex-mediated inflammation in arthritis models.
| M.Wt | 580.4595 | |
| Formula | C23H26FN6O9P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]- |
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1. Braselmann S, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.
2. Chen L, et al. Blood. 2008 Feb 15;111(4):2230-7.
3. Suljagic M, et al. Blood. 2010 Dec 2;116(23):4894-905.
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