Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Freselestat
Catalog No.: PC-60485Not For Human Use, Lab Use Only.
Freselestat (ONO 6818) is a potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Freselestat (ONO 6818) is a potent, selective and orally active human neutrophil elastase (HNE) inhibitor with Ki of 12 nM.
ONO 6818 dispalys >100-fold selectivity over a panel of related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase.
ONO 6818 attenuates HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count, inhibits acute lung injury induced by HNE in rats.
| M.Wt | 452.515 | |
| Formula | C23H28N6O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Ohmoto K, et al. J Med Chem. 2000 Dec 28;43(26):4927-9.
2. Odagaki Y, et al. Bioorg Med Chem. 2001 Mar;9(3):647-51.
3. Kuraki T, et al. Am J Respir Crit Care Med. 2002 Aug 15;166(4):496-500.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
