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Chemical Structure : Fulvestrant
CAS No.: 129453-61-8
Catalog No.: PC-21622Not For Human Use, Lab Use Only.
Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $118 | In stock | |
| 100 mg | $158 | In stock | |
| 200 mg | $228 | In stock | |
| 1 g | $398 | In stock | |
| 5 g | Get quote |
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Fulvestrant (ICI 182780) is a steroidal antiestrogen, and potent, specific estrogen receptor (ER) antagonist with IC50 of 0.94 nM.
Fulvestrant (ICI 182780) effectively inhibits the growth of ER-positive MCF-7 cells with IC50 of 0.29 nM.
Fulvestrant (ICI 182780) is a more effective inhibitor of MCF-7 growth than 4'-hydroxytamoxifen.
Fulvestrant (ICI 182780) exhibits antitumor activity in xenografts of MCF-7 and Br10 human breast cancers in nude mice.
| M.Wt | 606.78 | |
| Formula | C32H47F5O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
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1. Yu X, et al. Mol Cancer. 2015 Dec 15;14:208.
2. Wakeling AE, et al. Cancer Res. 1991 Aug 1;51(15):3867-73.
3. Brünner N, et al. Cancer Res. 1993 Jul 15;53(14):3229-32.
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