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Chemical Structure : Fumarase-IN-2 sodium
CAS No.:
Catalog No.: PC-42019Not For Human Use, Lab Use Only.
A cell-permeable small molecule inhibitor of Fumarase (fumarate hydratase), an enzyme of the tricarboxylic acid cycle (TCA cycle).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $280 | In stock | |
| 10 mg | $400 | In stock | |
| 25 mg | $800 | In stock | |
| 50 mg | $1280 | In stock |
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A cell-permeable small molecule inhibitor of Fumarase (fumarate hydratase), an enzyme of the tricarboxylic acid cycle (TCA cycle); elicits a nutrient-dependent cytotoxicity in a number of cancer cell lines, and displays increased growth-inhibitory activity toward SW620 cell line grown in the absence of glucose (mean IC50=2.2 uM).
| M.Wt | 440.4668 | |
| Formula | C25H25N2NaO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10.66 mg/mL |
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| Chemical Name/SMILES |
3aH-Indole-3a-carboxylic acid, 1-([1,1'-biphenyl]-4-ylmethyl)-1,2,3,4,5,6-hexahydro-3-[2-(methylamino)-2-oxoethyl]-2-oxo-, (3R,3aS)-rel-,sodium salt |
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1. Takeuchi T, et al. J Am Chem Soc. 2015 Jan 21;137(2):564-7.
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