Catalog No.: PC-63300Not For Human Use, Lab Use Only.
Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor (FZD7), inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM.
Fz7-21 is a potent, selective peptide inhibitor of Frizzled 7 receptor (FZD7), inhibits exogenous WNT3A stimulated Wnt-β-catenin signaling in HEK293 cells with IC50 of 100 nM.
Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC50 of 50 nM.
Fz7-21 shows isoform-selective binding to the Fc-tagged FZD1, FZD2 and FZD7 CRDs with EC50 of 19-58 nM, whereas little to no binding to the FZD4, FZD5, FZD8, FZD9 or FZD10 CRDs.
Fz7-21 impaires Wnt signaling in cultured cells and stem cell function in intestinal organoids.
