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FzM1.8

Chemical Structure : FzM1.8

CAS No.: 2204290-85-5

FzM1.8 (FzM 1.8;Fzd4 agonist FzM1.8)

Catalog No.: PC-60975Not For Human Use, Lab Use Only.

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.

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Purity & Documentation Purity: 99.35% (HPLC) Select Batch:

Biological Activity

FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.
FzM1.8 biases FZD4 signaling toward a FZD4/PI3K axis that culminates into transactivation of β-catenin/TCF activity by the histone acetyltransferase CBP/p300.
FzM1.8 preserves stemness and promotes proliferation of undifferentiated cells.

Physicochemical Properties

M.Wt 322.32
Formula C18H14N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-Hydroxy-5-(3-(naphthalen-2-yl)ureido)benzoic acid

References

1. Riccio G, et al. Biochemistry. 2018 Jan 2. doi: 10.1021/acs.biochem.7b01087.

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