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Chemical Structure : G244-LM
CAS No.: 1563007-08-8
Catalog No.: PC-38484Not For Human Use, Lab Use Only.
G244-LM is a potent and specific small-molecule tankyrase inhibitor, inhibits Wnt3a-induced signaling in HEK293 human and 10T1/2 mouse cells in a reporter assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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G244-LM is a potent and specific small-molecule tankyrase inhibitor, inhibits Wnt3a-induced signaling in HEK293 human and 10T1/2 mouse cells in a reporter assay.
G244-LM reduces Wnt/β-catenin signaling by preventing poly(ADP-ribosyl)ation-dependent AXIN degradation, thereby promoting β-catenin destabilization.
G244-LM inhibits growth of mouse intestinal organoids (IC50 = 0.11 µM) and organoid spheroids cultured from small intestine adenomas isolated from ApcMin mice.
| M.Wt | 406.519 | |
| Formula | C18H22N4O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3,5,7,8-tetrahydro-2-[4-[2-(methylsulfonyl)phenyl]-1-piperazinyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
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1. Ted Lau, et al. Cancer Res. 2013 May 15;73(10):3132-44.
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