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Chemical Structure : G907
Catalog No.: PC-63482Not For Human Use, Lab Use Only.
G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.
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G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM; traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket, inhibits the growth of wild-type E. coli and Klebsiella pneumoniae with MIC of 5.6 ug/ml.
| M.Wt | 433.932 | |
| Formula | C26H24ClNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ho H, et al. Nature. 2018 May 2. doi: 10.1038/s41586-018-0083-5.
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