You are here:Home-Chemical Inhibitors & Agonists-Wnt/Notch/Hedgehog-Gli-GANT 58
GANT 58

Chemical Structure : GANT 58

CAS No.: 64048-12-0

GANT 58 (NSC 75503;GANT58;GANT-58;NSC-75503)

Catalog No.: PC-43461Not For Human Use, Lab Use Only.

GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.

Packing Price Stock Quantity
25 mg $115 In stock
50 mg $195 In stock
100 mg $365 In stock
250 mg $625 In stock

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM; efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth in an in vivo xenograft model of human prostate cancer cells harboring downstream activation of the Hh pathway.

Physicochemical Properties

M.Wt
Formula C24H16N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-

References

1. Lauth M, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.

2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: