Chemical Structure : GANT 58
CAS No.: 64048-12-0
Catalog No.: PC-43461Not For Human Use, Lab Use Only.
GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
Packing | Price | Stock | Quantity |
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25 mg | $115 | In stock | |
50 mg | $195 | In stock | |
100 mg | $365 | In stock | |
250 mg | $625 | In stock |
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GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM; efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth in an in vivo xenograft model of human prostate cancer cells harboring downstream activation of the Hh pathway.
M.Wt | ||
Formula | C24H16N4S | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis- |
1. Lauth M, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60.
2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.
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