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Chemical Structure : GDC-0084
CAS No.: 1382979-44-3
Catalog No.: PC-45766Not For Human Use, Lab Use Only.
Paxalisib (GDC-0084, RG-7666) is a potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $318 | In stock | |
| 100 mg | $528 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Paxalisib (GDC-0084, RG-7666) is a potent, selective, brain penetrant dual inhibitor of class I PI3Ks and mTOR with Ki of 2/46/3/10/70 nM for PI3Kα/β/δ/γ/mTOR, respectively.
Paxalisib (GDC-0084, RG-7666) is highly selective against a panel of 229 kinases (IC50>1 uM).
Paxalisib (GDC-0084, RG-7666) shows antiproliferative (EC50 =0.3-1.1 uM) in 5 GBM cell lines.
Paxalisib (GDC-0084, RG-7666) significantly and dose-dependently inhibits tumor growth in a subcutaneous U87 tumor xenograft model of glioblastoma in mice.
| M.Wt | 382.4197 | |
| Formula | C18H22N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 6 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
2-Pyrimidinamine, 5-[8,9-dihydro-6,6-dimethyl-4-(4-morpholinyl)-6H-[1,4]oxazino[4,3-e]purin-2-yl]- |
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1. Heffron TP, et al. ACS Med Chem Lett. 2016 Feb 16;7(4):351-6.
2. Salphati L, et al. Drug Metab Dispos. 2016 Dec;44(12):1881-1889.
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