Catalog No.: PC-25916Not For Human Use, Lab Use Only.
GDC-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins, binds to XIAP BIR3 domain, BIR domain of ML-IAP, and BIR3 domains of cIAP1 and cIAP2 with Ki of 28, 14, 17, and 43 nM, respectively.
GDC-0152 is a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins, binds to XIAP BIR3 domain, BIR domain of ML-IAP, and BIR3 domains of cIAP1 and cIAP2 with Ki of 28, 14, 17, and 43 nM, respectively. GDC-0152 promotes degradation of cIAP1, induces activation of caspase-3/7, and lead to decreased viability of breast cancer cells without affecting normal mammary epithelial cells. GDC-0152 (10-100 mg/kg) inhibits tumor growth when dosed orally in the MDA-MB-231 breast cancer xenograft model.
