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Chemical Structure : GDC-0326
CAS No.: 1282514-88-8
Catalog No.: PC-60166Not For Human Use, Lab Use Only.
GDC0326 (GDC-0326) is a potent, selective, orally available PI3Kα inhibitor with Ki of 0.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | Get quote |
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GDC0326 (GDC-0326) is a potent, selective, orally available PI3Kα inhibitor with Ki of 0.2 nM.
GDC0326 displays 133, 20 and 33-fold selectivity over PI3Kβ, PI3Kδ and PI3Kγ, respectively.
GDC0326 inhibits MCF7-neo/HER2 and PC3 cells proliferation with IC50 of 0.1 uM and 2.2 uM, respectively.
GDC0326 reduces tumor growth as well as vascular area in vivo, also reduces the incidence of liver and lymph node metastasis.
| M.Wt | 382.424 | |
| Formula | C19H22N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide |
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1. Heffron TP, et al. J Med Chem. 2016 Feb 11;59(3):985-1002.
2. Soler A, et al. Clin Cancer Res. 2016 Dec 1;22(23):5805-5817.
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