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Chemical Structure : GDC-0425
CAS No.: 1200129-48-1
Catalog No.: PC-60278Not For Human Use, Lab Use Only.
GDC-0425 (RG7602) is a potent, selective and orally active Chk1 inhibitor.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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GDC-0425 (RG7602) is a potent, selective and orally active Chk1 inhibitor.
GDC-0425 (RG7602) enhances gemcitabine efficacy in tumor xenograft models.
GDC-0425 (RG7602) shows greater chemopotentiation in cancer cell lines lacking p53 activity.
| M.Wt | 321.384 | |
| Formula | C18H19N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile |
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1. Takahashi RH, et al. Drug Metab Dispos. 2017 May;45(5):430-440.
2. Infante JR, et al. Clin Cancer Res. 2017 May 15;23(10):2423-2432.
3. Lee HJ, et al. Mol Cancer Ther. 2017 Apr;16(4):694-704.
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